加拿大pc28

Zhang Lei

Education and Research Experience

  • 1991 – 1995   B.S. in Biochemistry, Department of Molecular Biology, Jilin University, Changchun, China
  • 1995 – 1998   M.S. in Biochemistry, National Laboratory of Enzyme Engineering, Jilin University, Changchun, China
  • 1998 – 2001   Ph.D. in Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China  
  • 2001 - 2008    Postdoctoral Research Fellow & assistant instructor, UT Southwestern Medical Center at Dallas
  • 2009 - 2022  Principle Investigator, IBCB,SIBS, Shanghai, China.
  • 2023 – present  Professor, Shanghai Jiaotong University, Department of Genetics and Developmental Science

Research Interests

Organ Development, Regeneration, and Tumorigenesis

Cell-fate decision is fundamental for multicellular organisms, ranking it the top important yet unresolved issue in the fields of life science. Hippo signaling is considered to sense and integrate multiple signals in environmental cues to drive cell-fate decision through modulating cell proliferation and differentiation, and is therefore of critical importance for organ size control, tissue homeostasis and regeneration. Despite the well-defined regulatory mechanisms of Hippo signaling activity, the molecular basis by which cells adopt different identities triggered by the Hippo pathway remains unclarified. We will continue to decipher the functional roles of some genes that are implicated in organ size control, tissue homeostasis and tumorigenesis, as well as the underlying mechanisms that determine cell-fate decision in different cell types. Our ultimate goal is to dissect the common, cell-type specific and evolutionally-conserved cell-fate decision mechanisms among distinct organs and species, thus providing novel insight into the pathogenesis of many diseases including cancers, as well as potential therapeutic intervention.

Selected Publications

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    Ruizeng Yang#, Liqiao Hu#, Jing Wang#, Jia Wang, Liang Yuan, Mengying Wu, Lingli He, Wentao Yu, Peihao Chen, Xiaoli Lu, Fangzheng Hu, Haijiao Zhang, Haoran Gao, Xiaodong Wang, Haoen Zhang, Yang Sun, Jinjin Xu, Jing Huang, Hu Zhou, Jidong Zhu, Fang Wei, Yunyun Jin, Yijun Gao, Qiang Fu, Xiangbing Qi*, Jing Yu*, Pilong Li*, Xiaojing He*, Lei Zhang*. Phase separation-based HTS identifies cobimetinib as a YAP-TEAD inhibitor that suppresses hyperactivated YAP-induced cancer progression. Science Translational Medicine  2026 Apr 22;18(846): eadu0814. (cover story)

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    Zhiyun Ren#, Yilin Zhao#, Wentao Yu, Xia Zhang, Xiaoxuan Song, Yanling Bao, Meng Hu, Lishuang Chen, Hao Yang, Bingkai Cheng, Cong Liu, Yunyun Jin*, Lei Zhang*, Bo Sun*. VGLL4-driven TEAD4 multimerization orchestrates DNA binding and YAP recruitment. Nat Communications 2026 Apr 11. doi: 10.1038/s41467-026-71766-5.

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    Haoen Zhang#, Zuoyun Wang#, Xiaodong Wang, Wentao Yu, Guoying Zhang, Haijiao Zhang, Yi Lu, Yang Sun, Tiantian Lu, Xiaoyu Li, Ruizeng Yang, Jiaqi Sun, Jinjin Xu, Shuo Huang, Xueyan Ma, Jiale Ren, Nan Tang, Zhonghua Cheng, Jing Yu, Fang Wei, Hu Zhou, Jinsong Li, Jun Qin, Yunyun Jin* & Lei Zhang*. VGLL4 modulates Paneth cells and sustains intestinal homeostasis. EMBO Reports  2026 Mar;27(5):1353-1382

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    Dan Jiang, Pengyue Li, Yi Lu, Jiaxin Tao, Xue Hao, Xiaodong Wang, Wei Wu, Jinjin Xu, Haoen Zhang, Xiaoyu Li, Yixing Chen, Yunyun Jin*, Lei Zhang*. A feedback loop between Paxillin and Yorkie sustains Drosophila intestinal homeostasis and regeneration. Nature communications  2025 Jan 10;16(1):570

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    Yang Sun, Henan Wei, Wentao Yu, Haoran Gao, Jinhui Li, Xiaoyu Li, Haijiao Zhang, Haoen Zhang, Sen Miao, Lihua Zhao, Ruizeng Yang, Jinjin Xu, Yi Lu, Fang Wei, Hu Zhou, Daming Gao, Yunyun Jin*, Lei Zhang*. The Actin Binding Protein Drebrin Disrupts NF2-LATS Kinases Complex Assembly to Facilitate Liver Tumorigenesis. Hepatology, 2025 May 1;81(5):1433-1451.

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    Lingli He# , Liang Yuan#, Wentao Yu,  Yang Sun, Dan Jiang, Xiaodong Wang, Xue Feng, Zuoyun Wang, Jinjin Xu, Ruizeng Yang, Wenxiang Zhang, Hua Feng, Hangzi Chen, Yi Arial Zeng, Lijian Hui, Qiao Wu, Yonglong Zhang,* & Lei Zhang*  A regulation loop between YAP and NR4A1 balances cell proliferation and apoptosis.  Cell Reports 2020, 33(3): 108284

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    Jinlong Suo#,Xue Feng#,Jiayi Li,Jinghui Wang,Zuoyun Wang*,Lei Zhang*, Weiguo Zou* VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited RUNX2 transcription. Science Advances 2020, 6(43):eaba4147

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    Xue Feng#, Tiantian Lu#, Jinhui Li, Ruizeng Yang, Liqiao Hu, Yi Ye, Feifei Mao, Lingli He, Jinjin Xu, Zuoyun Wang, Yingbin Liu, Yonglong Zhang, Hongbin Ji, Yun Zhao, Shuqun Cheng*, Wei Tian* and Lei Zhang* The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice. Hepatology 2020 Jun;71(6):1988-2004

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    Xue Hao, Shimin Wang, Yi Lu, Wentao Yu, Pengyue Li, Dan Jiang, Tong Guo, Mengjie Li, Jinhui Li, Jinjin Xu, Wenqing Wu, Margaret S. Ho*, Lei Zhang*  Lola regulates Drosophila adult midgut homeostasis via non-canonical Hippo signaling. eLife, 2020, 9:e47542

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    Xue Feng#, Zuoyun Wang#, Fei Wang#, Tiantian Lu, Jinjin Xu, Xueyan Ma, Jinhui Li, Lingli He, Wenxiang Zhang, Sheng Li, Wenjun Yang, Shu Zhang, Gaoxiang Ge, Yun Zhao, Ping Hu* and Lei Zhang* Dual function of VGLL4 in muscle regeneration. The EMBO Journal, 2019,38(17): e101051

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